Bioresponsive tooth-mounted sensors track what you eat

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High-tech wearables are nearly everywhere. Now a new tooth-mounted biosensor take measurements from inside the mouth.

Monitoring in real time what happens in and around our bodies can be invaluable in the context of health care or clinical studies, but not so easy to do. That could soon change thanks to new, miniaturized sensors developed by researchers at the Tufts University School of Engineering that, when mounted directly on a tooth and communicating wirelessly with a mobile device, can transmit information on glucose, salt and alcohol intake. Future adaptations of these sensors could enable the detection and recording of a wide range of nutrients, chemicals and physiological states.

Previous wearable devices for monitoring dietary intake suffered from limitations such as requiring the use of a mouth guard, bulky wiring, or necessitating frequent replacement as the sensors rapidly degraded. Tufts engineers sought a more adoptable technology and developed a sensor with a mere 2mm x 2mm footprint that can flexibly conform and bond to the irregular surface of a tooth. In a similar fashion to the way a toll is collected on a highway, the sensors transmit their data wirelessly in response to an incoming radiofrequency signal.

Bioresponsive sandwich sensors

The sensors are made up of three sandwiched layers: a central “bioresponsive” layer that absorbs the nutrient or other chemicals to be detected, and outer layers consisting of two square-shaped gold rings. Together, the three layers act like a tiny antenna, collecting and transmitting waves in the radiofrequency spectrum. As an incoming wave hits the sensor, some of it is cancelled out and the rest transmitted back, just like a patch of blue paint absorbs redder wavelengths and reflects the blue back to our eyes.

The sensor, however, can change its “color.” For example, if the central layer takes on salt, or ethanol, its electrical properties will shift, causing the sensor to absorb and transmit a different spectrum of radiofrequency waves, with varying intensity. That is how nutrients and other analytes can be detected and measured.

In theory the bioresponsive layer in these sensors can be modified to target other chemicals. And the researchers have extended common RFID (radiofrequency ID) technology to a sensor package that can dynamically read and transmit information on its environment, whether it is affixed to a tooth, to skin, or any other surface.

 

 

A miniaturized sensor mounted on a tooth. (Image: SilkLab, Tufts University).

A miniaturized sensor mounted on a tooth. (Image: SilkLab, Tufts University).